The inExpose is fully automated where computer and software control permit the researcher to accurately define and repeat their protocol. Pump profiles can be time-varying and allow for reproducible exposure profiles. With unparalleled precision and accurate delivery of the toxin or compound, the inExpose allows researchers to have a standardized animal model. With its size and reproducibility, fewer subjects may be needed per study group.
Several studies have utilized both SCIREQ’s inExpose and flexiVent systems for their respiratory research including North ML et al. Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma. Respir Res. 2011 Feb 3;12:19.
of users would recommend SCIREQ equipment
of SCIREQ users are happy with their decision to buy SCIREQ products.
of SCIREQ users are happy with the support and service provided.
With almost two decades of research and development, we have refined the flexiVent system to offer researchers the most detailed measurements in preclinical respiratory mechanics.
The flexiVent solution is accurate, reproducible and proven.
The flexiVent is a sensitive device that offers precise control of experimental conditions, allowing researchers to determine functional phenotypes (see Phenotyping Cystic Fibrosis with the flexiVent), detect differences in disease severity (see COX-2-derived prostacyclin protects against bleomycin-induced pulmonary fibrosis) and much more.
Furthermore, distinction between a subject’s airway versus tissue mechanics can be discerned in a matter of seconds, a detailed measurement unique to the flexiVent (see Assessing Airway Hyperresponsiveness using flexiVent). The flexiVent is comprehensive and easily permits a variety of measurements using a single protocol, providing the most information within one platform.
Detailed insights are obtained rapidly, resulting in fewer false positives, critical for drug development studies (see The flexiVent in the Asthma Drug Development Process) and allowing for higher throughput without sacrificing measurement quality.
The flexiVent is the only system currently available that combines forced expirations with standard mechanics measurements in a single set-up.
Automated protocols are executed with a mouse click and offer precise control whereby each measurement is taken at the same timepoint, in the same manner, for each subject. This allows accurate comparison between groups in real-time without further analysis, as evidenced during administration of inhaled aerosol delivery or when using a micro-CT scanner gated with ventilation (read Gated Thoracic Imaging with the flexiVent).
The flexiVent eliminates environmental conditions which may impact the measurements. Aspects of the protocol are seamlessly standardized including tidal volume, breathing rate, lung history and other ventilation parameters, ensuring the only true variable is the subject. For instance, our protocols automatically include controlled deep inflations to reset the subject’s lung history, bringing them back to baseline conditions.
With unparalleled accuracy and reproducibility, studies require fewer subjects. The typical flexiVent study group size is less than five subjects, resulting in less time and cost.
Thorough validation of SCIREQ products occurs both by our experienced in-house scientific team and in collaboration with well-established members of the research community. The flexiVent is trusted and highly recommended by many top scientists and reviewers as featured in over 4,420 flexiVent publications covering a wide range of applications.
of users would recommend SCIREQ equipment
of SCIREQ users are happy with their decision to buy SCIREQ products.
of SCIREQ users are happy with the support and service provided.
Save time evaluating SCIREQ equipment by having a SCIREQ Application Specialist conduct a custom
literature research. Researchers will receive an email report showing SCIREQ publications relevant to their specific application research area, along with custom equipment recommendations and commentary.
